The systematic collection of information for patients on renal replacement therapy (RRT) has been a challenge in most countries. Despite the importance of having accurate data on these patients, there is still no national system of registration that provides annually reliable epidemiological and economical data. In Brazil, the RRT procedures are billed through the subsystem APAC (Authorization of Procedures of High Complexity) which, although designed for administrative purposes, contains information that may support monitoring of the line of care to patients with terminal chronic renal disease. The study objective was to describe the treatment of the information contained in the National Database for RRT, discuss their potential, presenting the profile of morbidity and mortality of patients in RRT, in addition to the expenses with such procedures, as examples. This is a non concurrent prospective study using the National Database for RRT as the data source. This base was extracted from sub-system APAC and the Mortality Information System (SIM ). It includes patients inserted in the base from 01/01/2000 to 31/12/2004 and with at least three consecutive month records. Each patient was followed until the occurrence of death or the end of the study. 141.677 patients were analyzed: 51.321 composed the survival cohort, 90.356 composed the new patients cohort (incidents). The following results were presented: profile, fees and rates of prevalence, incidence and mortality rate. The aggregation of data from Health Information Systems, made it possible to get information about morbidity and mortality, services delivery and patients survival on RRT. It was also possible to perform a RRT cost-effectiveness analysis.